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The Radium Girls: The Dark Story of America's Shining Women
by Kate Moore

Language

English

Pages

405

Publication Date

April 18, 2017

Product Description
Customer Reviews
<p><strong>A<em> New York Times</em>, <em>USA Today, </em>and<em> Wall Street Journal</em> Bestseller!</strong><br /><strong>Emma Watson's Our Shared Shelf Bookclub Selection - May/June 2018 </strong></p><p>"<strong>the glowing ghosts of the radium girls haunt us still</strong>."—NPR Books </p><p><em>The incredible true story of the women who fought America's Undark danger</em></p><p>The Curies' newly discovered element of radium makes gleaming headlines across the nation as the fresh face of beauty, and wonder drug of the medical community. From body lotion to tonic water, the popular new element shines bright in the otherwise dark years of the First World War.</p><p>Meanwhile, hundreds of girls toil amidst the glowing dust of the radium-dial factories. The glittering chemical covers their bodies from head to toe; they light up the night like industrious fireflies. With such a coveted job, these "shining girls" are the luckiest alive — until they begin to fall mysteriously ill.</p><p>But the factories that once offered golden opportunities are now ignoring all claims of the gruesome side effects, and the women's cries of corruption. And as the fatal poison of the radium takes hold, the brave shining girls find themselves embroiled in one of the biggest scandals of America's early 20th century, and in a groundbreaking battle for workers' rights that will echo for centuries to come. </p><p>Written with a sparkling voice and breakneck pace, <em>The Radium Girls</em> fully illuminates the inspiring young women exposed to the "wonder" substance of radium, and their awe-inspiring strength in the face of almost impossible circumstances. Their courage and tenacity led to life-changing regulations, research into nuclear bombing, and ultimately saved hundreds of thousands of lives...</p>
How to Change Your Mind: What the New Science of Psychedelics Tea...
by Michael Pollan

Language

English

Pages

474

Publication Date

May 15, 2018

Product Description
Customer Reviews
<b><b><b><b><i>New York Times Book Review</i> 10 Best Books of 2018</b></b><br /><br />A<i> New York Times </i>Notable Book <br /><br />The #1 <i>New York Times</i> bestseller.<br /><br />A brilliant and brave investigation into the medical and scientific revolution taking place around psychedelic drugs--and the spellbinding story of his own life-changing psychedelic experiences </b></b><br /><br />When Michael Pollan set out to research how LSD and psilocybin (the active ingredient in magic mushrooms) are being used to provide relief to people suffering from difficult-to-treat conditions such as depression, addiction and anxiety, he did not intend to write what is undoubtedly his most personal book. But upon discovering how these remarkable substances are improving the lives not only of the mentally ill but also of healthy people coming to grips with the challenges of everyday life, he decided to explore the landscape of the mind in the first person as well as the third. Thus began a singular adventure into various altered states of consciousness, along with a dive deep into both the latest brain science and the thriving underground community of psychedelic therapists. Pollan sifts the historical record to separate the truth about these mysterious drugs from the myths that have surrounded them since the 1960s, when a handful of psychedelic evangelists inadvertently catalyzed a powerful backlash against what was then a promising field of research.<br /><br />A unique and elegant blend of science, memoir, travel writing, history, and medicine, <i>How to Change Your Mind</i> is a triumph of participatory journalism. By turns dazzling and edifying, it is the gripping account of a journey to an exciting and unexpected new frontier in our understanding of the mind, the self, and our place in the world. The true subject of Pollan's "mental travelogue" is not just psychedelic drugs but also the eternal puzzle of human consciousness and how, in a world that offers us both suffering and joy, we can do our best to be fully present and find meaning in our lives.
Bottle of Lies: The Inside Story of the Generic Drug Boom
by Katherine Eban

Language

English

Pages

512

Publication Date

May 14, 2019

Product Description
Customer Reviews
<p><strong>A <em>NEW YORK TIMES</em> BESTSELLER </strong></p><p><strong>From an award-winning journalist, an explosive narrative investigation of the generic drug boom that reveals fraud and life-threatening dangers on a global scale—<em>The Jungle</em> for pharmaceuticals</strong></p><p>Many have hailed the widespread use of generic drugs as one of the most important public-health developments of the twenty-first century. Today, almost 90 percent of our pharmaceutical market is comprised of generics, the majority of which are manufactured overseas. We have been reassured by our doctors, our pharmacists and our regulators that generic drugs are identical to their brand-name counterparts, just less expensive. But is this really true?</p><p>Katherine Eban’s <em>Bottle of Lies</em> exposes the deceit behind generic-drug manufacturing—and the attendant risks for global health. Drawing on exclusive accounts from whistleblowers and regulators, as well as thousands of pages of confidential FDA documents, Eban reveals an industry where fraud is rampant, companies routinely falsify data, and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit, confident in their ability to fool inspectors. Meanwhile, patients unwittingly consume medicine with unpredictable and dangerous effects.</p><p>The story of generic drugs is truly global. It connects middle America to China, India, sub-Saharan Africa and Brazil, and represents the ultimate litmus test of globalization: what are the risks of moving drug manufacturing offshore, and are they worth the savings?  </p><p>A decade-long investigation with international sweep, high-stakes brinkmanship and big money at its core, <em>Bottle of Lies</em> reveals how the world’s greatest public-health innovation has become one of its most astonishing swindles.</p><p> </p>
Dopesick: Dealers, Doctors, and the Drug Company that Addicted Am...
by Beth Macy

Language

English

Pages

385

Publication Date

August 07, 2018

Product Description
Customer Reviews
<b>An instant <i>New York Times </i>bestseller, <i>Dopesick </i>is the only book to tell the full story of the opioid crisis, from the boardroom to the courtroom and into the living rooms of Americans struggling to save themselves and their families: "masterfully interlaces stories of communities in crisis with dark histories of corporate greed and regulatory indifference" (<i>New York Times</i>) from a journalist who has lived through it.</b><br />In this extraordinary work, Beth Macy takes us into the epicenter of a national drama that has unfolded over two decades. From the labs and marketing departments of big pharma to local doctor's offices; wealthy suburbs to distressed small communities in Central Appalachia; from distant cities to once-idyllic farm towns; the spread of opioid addiction follows a tortuous trajectory that illustrates how this crisis has persisted for so long and become so firmly entrenched. Beginning with a single dealer who lands in a small Virginia town and sets about turning high school football stars into heroin overdose statistics, Macy sets out to answer a grieving mother's question-why her only son died-and comes away with a gripping, unputdownable story of greed and need. From the introduction of OxyContin in 1996, Macy investigates the powerful forces that led America's doctors and patients to embrace a medical culture where overtreatment with painkillers became the norm. In some of the same communities featured in her bestselling book <i>Factory Man</i>, the unemployed use painkillers both to numb the pain of joblessness and pay their bills, while privileged teens trade pills in cul-de-sacs, and even high school standouts fall prey to prostitution, jail, and death.<br /><br /> Through unsparing, compelling, and unforgettably humane portraits of families and first responders determined to ameliorate this epidemic, each facet of the crisis comes into focus. In these politically fragmented times, Beth Macy shows that one thing uniting Americans across geographic, partisan, and class lines is opioid drug abuse. But even in the midst of twin crises in drug abuse and healthcare, Macy finds reason to hope and ample signs of the spirit and tenacity that are helping the countless ordinary people ensnared by addiction build a better future for themselves, their families, and their communities.<br /><br /> <b>"An impressive feat of journalism, monumental in scope and urgent in its implications."</b> -<b> Jennifer Latson, <i>The Boston Globe</i></b><br /><br /> <br /><br /><br />
Fentanyl, Inc.: How Rogue Chemists Are Creating the Deadliest Wav...
by Ben Westhoff

Language

English

Pages

356

Publication Date

September 03, 2019

Product Description
Customer Reviews
A deeply human story, <i>Fentanyl, Inc.</i> is the first deep-dive investigation of a hazardous and illicit industry that has created a worldwide epidemic, ravaging communities and overwhelming and confounding government agencies that are challenged to combat it. “A whole new crop of chemicals is radically changing the recreational drug landscape,” writes Ben Westhoff. “These are known as Novel Psychoactive Substances (NPS) and they include replacements for known drugs like heroin, cocaine, ecstasy, and marijuana. They are synthetic, made in a laboratory, and are much more potent than traditional drugs”—and all-too-often tragically lethal.<p>Drugs like fentanyl, K2, and Spice—and those with arcane acronyms like 25i-NBOMe— were all originally conceived in legitimate laboratories for proper scientific and medicinal purposes. Their formulas were then hijacked and manufactured by rogue chemists, largely in China, who change their molecular structures to stay ahead of the law, making the drugs’ effects impossible to predict. Westhoff has infiltrated this shadowy world. He tracks down the little-known scientists who invented these drugs and inadvertently killed thousands, as well as a mysterious drug baron who turned the law upside down in his home country of New Zealand. Westhoff visits the shady factories in China from which these drugs emanate, providing startling and original reporting on how China’s vast chemical industry operates, and how the Chinese government subsidizes it. Poignantly, he chronicles the lives of addicted users and dealers, families of victims, law enforcement officers, and underground drug awareness organizers in the U.S. and Europe. Together they represent the shocking and riveting full anatomy of a calamity we are just beginning to understand. From its depths, as Westhoff relates, are emerging new strategies that may provide essential long-term solutions to the drug crisis that has affected so many.</p>
What the Eyes Don't See: A Story of Crisis, Resistance, and Hope ...
by Mona Hanna-Attisha

Language

English

Pages

352

Publication Date

June 19, 2018

Product Description
Customer Reviews
<b><b>A <i>NEW YORK TIMES </i>NOTABLE BOOK • </b>The dramatic story of the Flint water crisis, by a relentless physician who stood up to power.</b><br /><br /><b>“Stirring . . . [a] blueprint for all those who believe . . . that ‘the world . . . should be full of people raising their voices.’”—<i>The New York Times</i></b><br /><br /><b>“Revealing, with the gripping intrigue of a Grisham thriller.” —<i>O: The Oprah Magazine</i></b><br /><br /> Here is the inspiring story of how Dr. Mona Hanna-Attisha, alongside a team of researchers, parents, friends, and community leaders, discovered that the children of Flint, Michigan, were being exposed to lead in their tap water—and then battled her own government and a brutal backlash to expose that truth to the world. Paced like a scientific thriller, <i>What the Eyes Don’t See </i>reveals how misguided austerity policies, broken democracy, and callous bureaucratic indifference placed an entire city at risk. And at the center of the story is Dr. Mona herself—an immigrant, doctor, scientist, and mother whose family’s activist roots inspired her pursuit of justice.<br /><br /> <i>What the Eyes Don’t See</i> is a riveting account of a shameful disaster that became a tale of hope, the story of a city on the ropes that came together to fight for justice, self-determination, and the right to build a better world for their—and all of our—children.<br /><br /><b>Praise for <i>What the Eyes Don’t See</i></b><br /><br />“It is one thing to point out a problem. It is another thing altogether to step up and work to fix it. Mona Hanna-Attisha is a true American hero.”<b>—Erin Brockovich </b><br /><br />“A clarion call to live a life of purpose.”<b>—<i>The Washington Post</i></b><br /><br />“Gripping . . . entertaining . . . Her book has power precisely because she takes the events she recounts so personally. . . . Moral outrage present on every page.”<b>—<i>The New York Times Book Review</i></b><br /><br />“Personal and emotional. . . She vividly describes the effects of lead poisoning on her young patients. . . . She is at her best when recounting the detective work she undertook after a tip-off about lead levels from a friend. . . . ‛Flint will not be defined by this crisis,’ vows Ms. Hanna-Attisha.”<b>—<i>The Economist</i></b><br /><br />“Flint is a public health disaster. But it was Dr. Mona, this caring, tough pediatrican turned detective, who cracked the case.”<b>—Rachel Maddow</b>
Stealing Fire: How Silicon Valley, the Navy SEALs, and Maverick S...
by , Jamie Wheal

Language

English

Pages

309

Publication Date

February 21, 2017

Product Description
Customer Reviews
<p><strong>NATIONAL BESTSELLER </strong></p><p><strong>CNBC and Strategy + Business Best Business Book of 2017</strong></p><p><strong>"Steven and Jamie have done a wonderful job of balancing the promises, perils, and how-to prescriptions of engineering peak states such as 'flow.'" </strong><strong>—</strong><strong>Tim Ferriss, #1 <em>New York Times </em>best-selling author of <em>The 4-Hour Workweek</em></strong></p><p></p>It’s the biggest revolution you’ve never heard of, and it’s hiding in plain sight. Over the past decade, Silicon Valley executives like Eric Schmidt and Elon Musk, Special Operators like the Navy SEALs and the Green Berets, and maverick scientists like Sasha Shulgin and Amy Cuddy have turned everything we thought we knew about high performance upside down. Instead of grit, better habits, or 10,000 hours, these trailblazers have found a surprising short cut. They're harnessing rare and controversial states of consciousness to solve critical challenges and outperform the competition. <p></p><p><em>New York Times</em> bestselling author Steven Kotler and high performance expert Jamie Wheal spent four years investigating the leading edges of this revolution—from the home of SEAL Team Six to the Googleplex, the Burning Man festival, Richard Branson’s Necker Island, Red Bull’s training center, Nike’s innovation team, and the United Nations’ Headquarters. And what they learned was stunning: In their own ways, with differing languages, techniques, and applications, every one of these groups has been quietly seeking the same thing: the boost in information and inspiration that altered states provide. </p><p>Today, this revolution is spreading to the mainstream, fueling a <em>trillion</em> dollar underground economy and forcing us to rethink how we can all lead richer, more productive, more satisfying lives. Driven by four accelerating forces—psychology, neurobiology, technology and pharmacology—we are gaining access to and insights about some of the most contested and misunderstood terrain in history. Stealing Fire is a provocative examination of what’s actually possible; a guidebook for anyone who wants to radically upgrade their life.</p><p></p>
Deep Medicine: How Artificial Intelligence Can Make Healthcare Hu...
by Eric Topol

Language

English

Pages

341

Publication Date

March 12, 2019

Product Description
Customer Reviews
<b>One of America's top doctors reveals how AI will empower physicians and revolutionize patient care </b> <br /> Medicine has become inhuman, to disastrous effect. The doctor-patient relationship--the heart of medicine--is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In <i>Deep Medicine</i>, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard. <br /> Innovative, provocative, and hopeful, <i>Deep Medicine</i> shows us how the awesome power of AI can make medicine better, for all the humans involved.
G Protein-Coupled Receptors - Modeling and Simulation (Advances i...
by Springer

Language

English

Pages

228

Publication Date

October 25, 2013

Product Description
Customer Reviews
G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated over the years, discovering ligands of these receptors with optimal therapeutic properties is not straightforward and has certainly been hampered for years by the lack of high-resolution structural information about these receptors. Luckily, there has been a steady increase of high-resolution crystal structures of these receptors since 2007, and this information, integrated with dynamic inferences from computational and experimental methods, holds great potential for the discovery of new, improved drugs. This book, which provides, for the first time, state-of-the-art views on modeling and simulation of GPCRs, is divided into 4 parts. In the first part, the impact of currently available GPCR crystal structures on structural modeling is discussed extensively as are critical insights from simulations in the second part of the book. The third part reports recent progress in rational ligand discovery and mathematical modeling, whereas the fourth part provides an overview of bioinformatics tools and resources that are available for GPCRs.
3D Printing of Pharmaceuticals (AAPS Advances in the Pharmaceutic...
by Springer

Language

English

Pages

240

Publication Date

August 06, 2018

Product Description
Customer Reviews
<p>3D printing is forecast to revolutionise the pharmaceutical sector, changing the face of medicine development, manufacture and use. Potential applications range from pre-clinical drug development and dosage form design through to the fabrication of functionalised implants and regenerative medicine. Within clinical pharmacy practice, printing technologies may finally lead to the concept of personalised medicines becoming a reality. This volume aims to be the <i>definitive </i>resource for anyone thinking of developing or using 3D printing technologies in the pharmaceutical sector, with a strong focus on the translation of printing technologies to a clinical setting. This text brings together leading experts to provide extensive information on an array of 3D printing techniques, reviewing the current printing technologies in the pharmaceutical manufacturing supply chain, in particular, highlighting the state-of-the-art applications in medicine and discussing modern drug product manufacture from a regulatory perspective. This book is a highly valuable resource for a range of demographics, including academic researchers and the pharmaceutical industry, providing a comprehensive inventory detailing the current and future applications of 3D printing in pharmaceuticals. </p><p><b>Abdul W. Basit </b>is Professor of Pharmaceutics at the UCL School of Pharmacy, University College London. Abdul’s research sits at the interface between pharmaceutical science and gastroenterology, forging links between basic science and clinical outcomes. He leads a large and multidisciplinary research group, and the goal of his work is to further the understanding of gastrointestinal physiology by fundamental research. So far, this knowledge has been translated into the design of new technologies and improved disease treatments, many of which are currently in late-stage clinical trials. He has published over 350 papers, book chapters and abstracts and delivered more than 250 invited research presentations. Abdul is also a serial entrepreneur and has filed 25 patents and founded 3 pharmaceutical companies (Kuecept, Intract Pharma, FabRx). </p><p>Abdul is a frequent speaker at international conferences, serves as a consultant to many pharmaceutical companies and is on the advisory boards of scientific journals, healthcare organisations and charitable bodies. He is the European Editor of the <i>International Journal of Pharmaceutics</i>.</p><p>Abdul was the recipient of the Young Investigator Award in Pharmaceutics and Pharmaceutical Technology from the American Association of Pharmaceutical Scientists (AAPS) and is the only non-North American scientist to receive this award. He was also the recipient of the Academy of Pharmaceutical Sciences (APS) award.</p><p><b>Simon Gaisford </b>holds a Chair in Pharmaceutics and is Head of the Department of Pharmaceutics at the UCL School of Pharmacy, University College London. He has published 110 papers, 8 book chapters and 4 authored books. His research is focused on novel technologies for manufacturing medicines, particularly using ink-jet printing and 3D printing, and he is an expert in the physico-chemical characterisation of compounds and formulations with thermal methods and calorimetry.</p>

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